disease

Parkinson's Disease

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Parkinson's Disease: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7018Connections

0Hypotheses

8Analyses

50Outgoing

50Incoming

Summary

Parkinson's Disease is a disease characterized by neurodegeneration research. Key relationships include: associated with, risk factor for, involved in. Associated with Chronic Viral Infections, Rapid Eye Movement Sleep Behavior Disorder. Connected to 130 entities in the SciDEX knowledge graph.

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Disease Info

Associated Genes	SNCA, SLC6A3, NDUFA9, Alpha-Synuclein, LAMP1, IGF2, TMEM175, α-Synuclein
Therapeutic Agents	Nsaid, Methylene Blue, Atremorine, Gentiopicroside, ACLY Inhibitor, ACLY Inhibitors
KG Connections	1037 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Parkinson_s_Disease["Parkinson's Disease"] -->|"associated"| Dopaminergic_Neurons["Dopaminergic Neurons"]
    Parkinson_s_Disease["Parkinson's Disease"] -->|"associated"| Substantia_Nigra["Substantia Nigra"]
    Parkinson_s_Disease["Parkinson's Disease"] -->|"causes"| Motor_Decline["Motor Decline"]
    Parkinson_s_Disease["Parkinson's Disease"] -->|"causes"| Cognitive_Decline["Cognitive Decline"]
    Parkinson_s_Disease["Parkinson's Disease"] -->|"causes"| Neurodegeneration["Neurodegeneration"]
    Parkinson_s_Disease["Parkinson's Disease"] -->|"associated"| Circadian_Rhythm["Circadian Rhythm"]
    SNCA["SNCA"] -->|"associated"| Parkinson_s_Disease["Parkinson's Disease"]
    SNCA_1["SNCA"] -->|"causes"| Parkinson_s_Disease["Parkinson's Disease"]
    Prosaposin_GPR37_IL_6_Axis["Prosaposin-GPR37-IL-6 Axis"] -->|"involved in"| Parkinson_s_Disease["Parkinson's Disease"]
    Gut_Microbiota["Gut Microbiota"] -->|"associated"| Parkinson_s_Disease["Parkinson's Disease"]
    style Parkinson_s_Disease fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (2873)

Target	Relation	Type	Str
Dopaminergic Neurons	associated_with	cell_type	0.95
Substantia Nigra	associated_with	cell_type	0.95
Motor Decline	causes	phenotype	0.95
Cognitive Decline	causes	phenotype	0.95
Neurodegeneration	causes	process	0.95
Circadian Rhythm	associated_with	process	0.95
Neuroinflammation	associated_with	process	0.95
Toxic Protein Accumulation	associated_with	process	0.95
Dopaminergic Neurons	causes	cell_type	0.95
Dopaminergic Neuron Loss	causes	process	0.95
Dopaminergic Neurodegeneration	causes	process	0.95
Neurodegenerative Diseases	associated_with	disease	0.95
bradykinesia	causes	phenotype	0.95
dopaminergic neurons	causes	cell_type	0.95
cognitive impairment	causes	phenotype	0.95
dopaminergic system	associated_with	pathway	0.93
Inflammatory Processes	associated_with	process	0.90
Type 2 Diabetes Mellitus	associated_with	disease	0.90
Depression	associated_with	disease	0.90
Neurons	targets	cell_type	0.90
Iron Accumulation	associated_with	process	0.90
akinesia	causes	phenotype	0.90
omission rate	associated_with	phenotype	0.90
Insulin Resistance	associated_with	process	0.85
Brain-Resident T Cells	associated_with	cell_type	0.85
Levodopa Response	correlates_with	phenotype	0.85
motor incoordination	causes	phenotype	0.85
functional performance	suppresses	phenotype	0.85
dorsolateral prefrontal cortex	associated_with	brain_region	0.85
Short-Chain Fatty Acids	correlates_with	compound	0.80
basal ganglia-thalamocortical circuit	associated_with	biological_process	0.80
prefrontal interhemispheric functional connectivity	modulates	phenotype	0.80
Adverse Drug Reactions	associated_with	phenotype	0.75
MAPL	associated_with	protein	0.75
Inflammation	associated_with	process	0.75
Vitamin D	associated_with	chemical	0.70
Neurodegenerative Diseases	interacts_with	disease	0.50
disease	interacts_with	disease	0.50
PARKINSON'S	interacts_with	concept	0.50
Pain	interacts_with	disease	0.50
Neuropathy	associated_with	disease	0.50
disease	associated_with	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50
PARKINSON'S	associated_with	concept	0.50
ALZHEIMER'S	interacts_with	concept	0.50
Neuron	protects_against	cell_type	0.50
disease	protects_against	disease	0.50
NEURONS	protects_against	concept	0.50
Substantia Nigra	protects_against	entity	0.50
PARKINSON'S	protects_against	concept	0.50

Incoming (4145)

Source	Relation	Type	Str
SNCA	associated_with	gene	0.95
SNCA	causes	gene	0.95
Prosaposin-GPR37-IL-6 Axis	involved_in	pathway	0.95
Gut Microbiota	associated_with	process	0.95
GBA	risk_factor_for	gene	0.95
SNCA	risk_factor_for	gene	0.95
LRRK2	risk_factor_for	gene	0.95
PRKN	risk_factor_for	gene	0.95
PINK1	risk_factor_for	gene	0.95
DJ1	risk_factor_for	gene	0.95
Neuroinflammation	contributes_to	process	0.95
Alpha-Synuclein	involved_in	protein	0.95
C3	involved_in	protein	0.95
α-Synuclein	causes	protein	0.95
SNCA	involved_in	gene	0.95
SNCA	component_of	protein	0.95
Mptp	causes	drug	0.95
Mitochondrial Dysfunction	contributes_to	process	0.95
Neuroinflammation	biomarker_for	process	0.95
Circadian Clock	associated_with	process	0.95
Α-SYNUCLEIN	causes	protein	0.95
LRRK2	causes	gene	0.95
GBA1	causes	gene	0.95
PRKN	causes	gene	0.95
PINK1	causes	gene	0.95
PARK7	causes	gene	0.95
VPS35	causes	gene	0.95
Dopaminergic Neurons	involved_in	cell_type	0.95
Alpha-Synuclein Accumulation	contributes_to	process	0.95
Alpha-Synuclein Aggregation	causes	mechanism	0.95
Alpha-Synuclein Aggregation	associated_with	process	0.95
Dopaminergic Neuronal Death	causes	process	0.95
PINK1	associated_with	gene	0.95
PRKN	associated_with	gene	0.95
ALPHA-SYNUCLEIN	involved_in	protein	0.95
Neurodegeneration	contributes_to	process	0.95
Pathological Processes	contributes_to	process	0.95
Neuroplasticity	associated_with	process	0.95
Rotenone	causes	compound	0.95
ALPHA-SYNUCLEIN AGGREGATES	contributes_to	protein	0.95
Levodopa	treats	drug	0.95
Pathological Protein Aggregation	causes	process	0.95
6-Ohda	causes	compound	0.95
ALPHA-SYNUCLEIN	associated_with	protein	0.95
LRRK2	contributes_to	gene	0.95
GBA1	contributes_to	gene	0.95
PRKN	contributes_to	gene	0.95
PINK1	contributes_to	gene	0.95
PARK7	contributes_to	gene	0.95
VPS35	contributes_to	gene	0.95

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (8)

Scientific analyses that reference this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Parkinson's Disease

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Pathway Diagram

Outgoing (2873)

Incoming (4145)

Targeting Hypotheses (0)

Mentioning Analyses (8)

How do oligodendrocytes initiate neuroinflammation in PD when microglia are trad

What molecular mechanisms underlie Atremorine's dramatic dopamine enhancement in

GBA-Synuclein Loop Therapeutics for PD

GBA-Synuclein Loop: Therapeutic Strategies for Parkinson's Disease

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

Related Papers (0)

Parkinson's Disease

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index